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Clinical Trials – Musculoskeletal

Our clinical research team has vast experience in musculoskeletal conditions. Our primary indication for this area of medical development is in osteoarthritis clinical trials.

Please see study list below for musculoskeletal clinical trials that have been conducted at Genesis Research Services.

A First-in-Human Open-Label Phase 1/2a Study to Evaluate Safety, Tolerability and Efficacy of a Single Intra-Articular Injection of Allogeneic Mesenchymal Stem Cells Selected for Integrin α10β1 (XSTEM-OA) in Adult Patients with Symptomatic Knee Osteoarthritis.
  • Year: 2023
  • Type: Musculoskeletal
  • Phase: First-in-Human, I, IIa
  • Indication: Knee Osteoarthritis
A Multiple Arm, Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm, Phase 2 Study of Intra-Articular Administration of an Allogeneic Human Placental Tissue Particulate (PTP-001) for the Treatment of Knee Osteoarthritis.
  • Year: 2022
  • Type: Musculoskeletal
  • Phase: II
  • Indication: Knee Osteoarthritis
A 5-year, Randomized, Double-blind, Placebo-controlled, Multi-center Study Assessing the Efficacy, Safety, and Tolerability of Intra-articular Regimens of LNA043 Versus Placebo in Patients With Symptomatic Knee Osteoarthritis (ONWARDS).
  • Year: 2021
  • Type: Musculoskeletal
  • Phase: IIb
  • Indication: Knee Osteoarthritis
Upadacitinib treatment patterns, achievement of treatment targets and maintenance of response in moderate to severe Rheumatoid Arthritis patients in real-world practice (UPHOLD).
  • Year: 2020
  • Type: Musculoskeletal
  • Phase: Post-Market
  • Indication: Rheumatoid Arthritis
Real World Effectiveness of Upadacitinib on Early and Sustained Pain Control in Radiographic Axial Spondyloarthritis (UPSTAND).
  • Year: 2021
  • Type: Musculoskeletal
  • Phase: Post-Market
  • Indication: Spondyloarthritis
A Randomized, Active-Controlled, Parallel Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis.
  • Year: 2021
  • Type: Musculoskeletal
  • Phase: IIIb, IV
  • Indication: Rheumatoid Arthritis
A Multicenter Open-Label Study Of Etanercept Withdrawal And Retreatment In Subjects With Non-Radiographic Axial Spondyloarthritis Who Achieved Adequate 24 Week Response.
  • Year: 2016
  • Type: Musculoskeletal
  • Phase: IV
  • Indication: Spondyloarthritis
A Phase 3b/4 Randomized Double-Blind Placebo Controlled Study Of Methotrexate (Mtx) Withdrawal In Subjects With Rheumatoid Arthritis (Ra) Treated With Tofacitinib 11mg Modified Release (Mr) Formulation.
  • Year: 2017
  • Type: Musculoskeletal
  • Phase: IIIb, IV
  • Indication: Rheumatoid Arthritis
A 12 Week Randomized, Double-Blind, Double Dummy, Parallel Group, Active And Placebo-Controlled, Multicenter Study To Assess The Efficacy And Safety Profile Of Pf-06650833 In Subjects With Active Rheumatoid Arthritis With An Inadequate Response To Methotrexate.
  • Year: 2017
  • Type: Musculoskeletal
  • Phase: II
  • Indication: Rheumatoid Arthritis
A Phase 3, Randomized, Double blind, Placebo controlled Study to Evaluate the Efficacy and Safety of Filgotinib in Subjects with Active Psoriatic Arthritis Who Have an Inadequate Response or are Intolerant to Biologic DMARD Therapy.
  • Year: 2020
  • Type: Musculoskeletal
  • Phase: III
  • Indication: Psoriatic Arthritis