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Clinical Trials – Musculoskeletal

Our clinical research team has vast experience in musculoskeletal conditions. Our primary indication for this area of medical development is in osteoarthritis clinical trials.

Please see study list below for musculoskeletal clinical trials that have been conducted at Genesis Research Services.

A Randomized, Active-Controlled, Parallel Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis.
  • Year: 2021
  • Type: Musculoskeletal
  • Phase: IIIb, IV
  • Indication: Rheumatoid Arthritis
A Multicenter Open-Label Study Of Etanercept Withdrawal And Retreatment In Subjects With Non-Radiographic Axial Spondyloarthritis Who Achieved Adequate 24 Week Response.
  • Year: 2016
  • Type: Musculoskeletal
  • Phase: IV
  • Indication: Spondyloarthritis
A Phase 3b/4 Randomized Double-Blind Placebo Controlled Study Of Methotrexate (Mtx) Withdrawal In Subjects With Rheumatoid Arthritis (Ra) Treated With Tofacitinib 11mg Modified Release (Mr) Formulation.
  • Year: 2017
  • Type: Musculoskeletal
  • Phase: IIIb, IV
  • Indication: Rheumatoid Arthritis
A 12 Week Randomized, Double-Blind, Double Dummy, Parallel Group, Active And Placebo-Controlled, Multicenter Study To Assess The Efficacy And Safety Profile Of Pf-06650833 In Subjects With Active Rheumatoid Arthritis With An Inadequate Response To Methotrexate.
  • Year: 2017
  • Type: Musculoskeletal
  • Phase: II
  • Indication: Rheumatoid Arthritis
A Phase 3, Randomized, Double blind, Placebo controlled Study to Evaluate the Efficacy and Safety of Filgotinib in Subjects with Active Psoriatic Arthritis Who Have an Inadequate Response or are Intolerant to Biologic DMARD Therapy.
  • Year: 2020
  • Type: Musculoskeletal
  • Phase: III
  • Indication: Psoriatic Arthritis
A Phase 3, Randomized, Double-blind, Placebo and Adalimumab-controlled Study to Evaluate the Efficacy and Safety of Filgotinib in Subjects with Active Psoriatic Arthritis Who Are Naïve to Biologic DMARD Therapy.
  • Year: 2020
  • Type: Musculoskeletal
  • Phase: III
  • Indication: Psoriatic Arthritis
A randomized, double-blind, placebo-controlled study of the safety and efficacy of AA4500 for the treatment of adhesive capsulitis of the shoulder.
  • Year: 2014
  • Type: Musculoskeletal
  • Phase: IIb
  • Indication: Other
An Open-label Historically Controlled Study to Assess the Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects with Multiple Dupuytren’s Contractures with Palpable Cords.
  • Year: 2012
  • Type: Musculoskeletal
  • Phase: IIIb
  • Indication: Other
Dose-Ranging Study of Multiple Subcutaneous Doses of LY2127399, an Anti-BAFF Human Antibody, in Participants with Active Rheumatoid Arthritis despite Ongoing Methotrexate Therapy.
  • Year: 2010
  • Type: Musculoskeletal
  • Phase: II
  • Indication: Rheumatoid Arthritis
A Study to Compare the Preference for Two Contrasting Paracetamol Formulations In The Management of Osteoarthritis Pain.
  • Year: 2008
  • Type: Musculoskeletal
  • Phase: IV
  • Indication: Knee Osteoarthritis
A Multi-Centre, Randomised, Double-Blind, Placebo Controlled, Parallel Group Exploratory Study to Investigate the Efficacy, Safety and Tolerability of AD 337 in the Treatment of Fibromyalgia in Female Subjects.
  • Year: 2007
  • Type: Musculoskeletal
  • Phase: II
  • Indication: Fibromyalgia
A Randomised Double-Blind, Placebo-and-Active-Control, Parallel-arm, Phase III Trial with Controlled Adjustment of Dose to Evaluate the Efficacy and Safety of CG5503 Extended –Release (ER) in Subjects with Moderate to Severe Pain Due to Osteoarthritis of the Knee.
  • Year: 2008
  • Type: Musculoskeletal
  • Phase: III
  • Indication: Knee Osteoarthritis
A Randomized, Double Blind, Parallel-Group Study of Cardiovascular Safety in Osteoarthritis or Rheumatoid Arthritis Patients with or At High Risk for Cardiovascular Disease Comparing Celecoxib with Naproxen and Ibuprofen.
  • Year: 2011
  • Type: Musculoskeletal
  • Phase: IV
  • Indication: Rheumatoid Arthritis
A Double Blind, Randomised, Parallel Group, Dose-Ranging Study Comparing FX006 to Commercially Available Triamcinolone Acetonide Injectable Suspension in Patients with Osteoarthritis of the Knee.
  • Year: 2012
  • Type: Musculoskeletal
  • Phase: II
  • Indication: Knee Osteoarthritis
A Multi centre, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Hydros and Hydros-TA Joint Therapies for Management of Pain Associated with Osteoarthritis in the Knee.
  • Year: 2015
  • Type: Musculoskeletal
  • Phase: III
  • Indication: Knee Osteoarthritis
A Double-Blind, Randomized, Single-Dose Study to Assess the Safety and Efficacy of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee.
  • Year: 2016
  • Type: Musculoskeletal
  • Phase: III
  • Indication: Knee Osteoarthritis
A Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of AXS-02 (Disodium Zoledronate Tetrahydrate) Administered Orally to Subjects with Knee Osteoarthritis Associated with Bone Marrow Lesions.
  • Year: 2016
  • Type: Musculoskeletal
  • Phase: IIa
  • Indication: Knee Osteoarthritis
A randomised, double-blind using blinded evaluator, placebo and active controlled, pilot study to evaluate the safety and efficacy of intra articular administration of Articul One in patient with symptomatic primary knee osteoarthritis.
  • Year: 2017
  • Type: Musculoskeletal
  • Phase: II
  • Indication: Knee Osteoarthritis
A Phase 2A, Randomized, Double-Blind, Placebo-Controlled, Multiple Center, Multiple-Dose Study to Assess the Efficacy and Safety of ZYN002 Administered as a Transdermal Gel to Patients with Knee Pain due to Osteoarthritis.
  • Year: 2017
  • Type: Musculoskeletal
  • Phase: IIa
  • Indication: Knee Osteoarthritis
A Phase IIa, Randomized, Double-blinded, Placebo-controlled, Dose-finding Study for Single-Dose Administration of TLC599 in Patients with Osteoarthritis (OA) of Knee.
  • Year: 2017
  • Type: Musculoskeletal
  • Phase: IIa
  • Indication: Knee Osteoarthritis
A Phase 3, Randomized, Double-blind, Placebo- and Active controlled Study to Evaluate the Efficacy and Safety of TLC599 in Patients with Osteoarthritis of the Knee.
  • Year: 2020
  • Type: Musculoskeletal
  • Phase: III
  • Indication: Knee Osteoarthritis