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Arthritis is a group of more than 100 health conditions that affect the joints in your body. Lots of people in Australia, about 1 in 6, live with some type of arthritis. Two common types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA). Each condition can really change how people live their lives. In this blog, you will read about the different symptoms and risk factors for each condition, and how they are diagnosed and treated.
Osteoarthritis is sometimes called “wear and tear” arthritis. It happens when the protective cushion between your bones breaks down over time.
OA often affects joints that bear weight, such as the knees, hips, and spine, but it can also affect the hands.
Symptoms include pain, stiffness, and less movement in the joints.
Rheumatoid arthritis is an autoimmune disease. It is the result of the body’s immune system attacking its own tissues by mistake.
RA mainly affects the lining of the joints, especially the hands, feet, knees, and hips, but it can affect other organs. It usually affects both sides of the body.
Symptoms include pain, swelling, and inflammation in the joints. It can also cause tiredness and fever.
Understanding these risk factors can help you to take steps to prevent osteoarthritis or rheumatoid arthritis and make smart lifestyle choices:
| Risk Factors | Osteoarthritis | Rheumatoid Arthritis |
| Age | Risk increases with age. | Often starts between 30 and 60 years but can happen at any age. |
| Gender | More likely in women, especially after menopause. | More likely in women. Hormonal changes during pregnancy and menopause may increase risk. |
| Genetics | Family history. | Family history. 65% of risk is linked to the Human Leukocyte Antigen (HLA) gene. |
| Weight | Being overweight puts more stress on the joints and greatly increases risk. | Being overweight may increase risk. |
| Work | Jobs involving repetitive stress on joints, such as kneeling and squatting. | – |
| Other | Previous joint injuries. | Some infections and pollutants. Smoking. |
The diagnosis of osteoarthritis and rheumatoid arthritis involves different approaches due to the distinct nature of each condition.
For both OA and RA, a clinical evaluation by a health practitioner will involve assessing the joint pain and other specific symptoms associated with each condition, as well as family history.
For OA, the doctor will want to know if you’ve had any previous joint injuries and what your occupation is.
Diagnosis of RA often involves blood tests to check for markers like rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibodies, and inflammation markers (CRP, ESR).
For OA, x-rays to look for narrowing of the joint space, bone spurs, and subchondral sclerosis. MIR or CT scans assess joint damage and soft tissue involvement.
For RA, x-rays, ultrasound, or MRI assess joint damage, inflammation, and erosion typical of RA.
Because they have different causes, the treatment approaches for osteoarthritis and rheumatoid arthritis are also different.
Treatment for OA focuses on managing the symptoms and enhancing joint function. These include:
Genesis Research Services conducts clinical trials for a range of arthritis conditions, including osteoarthritis and rheumatoid arthritis. To view currently recruiting studies or register your interest for future studies, click here or call us on (02) 4985 1860.
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© Genesis Research Services, 2023