A Phase 4, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Tolerability of Rimegepant for the Prevention of Migraine in Adults with a History of Inadequate Response to Oral Preventive Medications
2023 | Pharmaceutical - Pain | Phase IV | Migraine
A Pilot Study Assessing Preliminary Safety and Efficacy of The ShiraTronics Migraine Therapy System in RELIEVing, Interrupting, and Preventing Chronic Migraine (RELIEV-CM).
2023 | Device | Phase Pilot | Migraine
A Prospective, Open-Label, Multi-Center Trial to Evaluate the Safety and Effectiveness of Ultra Low Frequency Spinal Cord Stimulation in Patients With Chronic Low Back Pain.
2023 | Device | Phase N/A | Back and/or Leg Pain, Chronic Trunk and/or Limb Pain
A First in Human Feasibility Study to Evaluate the Safety and Effectiveness of the BIOTRONIK Prospera™ SCS System With HomeStream™ Remote Management.
2022 | Device | Phase First-in-Human | Back and/or Leg Pain
Evaluation of Long-term Patient Experience with a Medtronic Closed-Loop SCS System (ClosedLoop SCS study).
2022 | Device | Phase N/A | Back and/or Leg Pain, Chronic Trunk and/or Limb Pain, Neck / Upper Limb Pain
Freshwater: A prospective, multicentre, single-arm feasibility study examining novel treatment delivery of the Evoke Spinal Cord Stimulator (SCS) System to treat patients with chronic pain of the trunk and/or limbs.
2021 | Phase Post-Market | Back and/or Leg Pain, Chronic Trunk and/or Limb Pain, Neck / Upper Limb Pain
Single-Arm, Multicenter, Study to Evaluate Safety and Efficacy of Ultra-Low Frequency Spinal Cord Stimulator in Subjects with Painful Diabetic Neuropathy.
2021 | Device | Phase Pre-Market | Painful Diabetic Neuropathy
A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain (RELIEF-2).
2019 | Device | Phase Post-Market | Back and/or Leg Pain, Chronic Trunk and/or Limb Pain, Neck / Upper Limb Pain
A Randomized, Controlled, Multi-Center, Non-inferiority Trial to Evaluate the Safety and Efficacy of Ultra-Low Frequency Spinal Cord Stimulation Compared to Traditional Spinal Cord Stimulation in Subjects with Chronic Back Pain with / without Leg Pain.
2020 | Device | Phase Pre-Market | Back and/or Leg Pain
A Prospective Trial to Assess the Safety and Performance of the Spinal Modulation Neurostimulator System in the Treatment of Chronic Pain.
2012 | Device | Phase N/A | Chronic Trunk and/or Limb Pain
Precision High-Rate Sub-perception Spinal Cord Stimulation for the Treatment of Chronic Intractable Pain.
2012 | Device | Phase N/A | Back and/or Leg Pain
Partnership for Advancement in Neuromodulation (PAIN): A Prospective Clinical Outcomes Registry.
2012 | Device | Phase Post-Market | Chronic Trunk and/or Limb Pain
SCS Heart Study- Spinal Cord Stimulation for heart Failure as a Restorative Treatment.
2013 | Device | Phase First-in-Human | Other
SubQStim: Interventional, Prospective, Multicenter, Randomized, Parallel-arm Study to Compare the Effectiveness of Peripheral Nerve Stimulation (PNS) Utilizing a Subcutaneous Lead Implant Technique (SQS) Plus Optimized Medical Management (OMM) Versus OMM
2013 | Device | Phase IV | Back and/or Leg Pain
OPTIONS Precision Spectra™ Neurostimulator System for the Treatment of Chronic Intractable Pain of the Trunk and/or Limbs.
2013 | Device | Phase N/A | Back and/or Leg Pain, Chronic Trunk and/or Limb Pain
An investigation into the therapeutic effect of electrical impulses with short pulse (SP) width on pain relief and quality of the spinal cord stimulation (SCS) in patients with intractable back and / or leg pain.
2013 | Device | Phase N/A | Back and/or Leg Pain
A Multicenter Prospective Observational Study on the Safety and Efficacy of High Frequency Spinal Cord Stimulation in Complex Regional Pain Syndrome Patients.
2013 | Device | Phase Post-Market | CRPS
BURST Pre-Market Clinical Study.
2014 | Device | Phase Pre-Market
A feasibility study evaluating the Saluda SCS system incorporating feedback control using Evoked Compound Action Potentials (ECAP) to aid in the accurate positioning of Spinal Cord Stimulation (SCS) leads.
2014 | Device | Phase Pre-Market | Back and/or Leg Pain, Chronic Trunk and/or Limb Pain
A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain (RELIEF).
2014 | Device | Phase Post-Market | Chronic Trunk and/or Limb Pain
Investigation of the ReActiv8® Implantable Stimulation System for Chronic Low Back Pain (ReActiv8-A).
2014 | Device | Phase Pre-Market | Back and/or Leg Pain
Multi-Centre, Prospective Clinical Trial of the Senza™ Spinal Cord Stimulation (SCS) System in the Treatment of Chronic Upper Limb and Neck Pain.
2016 | Device | Phase Pre-Market | Neck / Upper Limb Pain
Avalon: A study to evaluate the safety and performance of a new Spinal Cord Stimulation System using automatic control to treat patients with chronic pain.
2016 | Device | Phase Pre-Market | Back and/or Leg Pain, Chronic Trunk and/or Limb Pain, Neck / Upper Limb Pain
ReActiv8 Implantable Neurostimulation System for Chronic Low Back Pain (ReActiv8-B).
2017 | Device | Phase Pre-Market | Back and/or Leg Pain
A Prospective, Single-Blinded, Dose-Response Study of SCS Therapy using Subthreshold Waveform Patterns in Patients with Chronic Neuropathic Low Back Pain.
2018 | Device | Phase N/A | Back and/or Leg Pain
A Prospective, Multicentre Study of Low Dose Targeted Drug Delivery (TDD) for Chronic Back Pain Patients who have Failed Spinal Cord Stimulation.
2019 | Device | Phase N/A | Back and/or Leg Pain
A Data Acquisition Study for the Tournicare Blood Pressure Monitor
2019 | Device | Phase Pre-Market | Healthy
Buffered GEnipin Microinvasive Device for Treatment of Low Back Pain from Degenerative Disc Disease – CE Marking Safety and Efficacy Study (GEM-SE).
2019 | Device | Phase II | Back and/or Leg Pain
A Multi-Center, Prospective Clinical Trial of Spinal Cord Stimulation with Varying Parameters for the Treatment of Chronic Back and/or Leg Pain.
2019 | Device | Phase N/A | Back and/or Leg Pain
Single-Arm, Multicenter, Study to Evaluate Safety and Efficacy of Low Frequency Spinal Cord Stimulator in Subjects with Low Back and/or Leg Pain.
2019 | Device | Phase First-in-Human | Back and/or Leg Pain
A global, multi-site observational clinical trial, a cross-sectional survey (paper) comparing women with and without an osteoporotic fracture (OF). Estimating Short-Term Indirect Cost and Physical Functioning Burden Associated with Osteoporotic Fractures.
2020 | Musculoskeletal | Phase N/A | Osteoporosis
A First-in-Human Open-Label Phase 1/2a Study to Evaluate Safety, Tolerability and Efficacy of a Single Intra-Articular Injection of Allogeneic Mesenchymal Stem Cells Selected for Integrin α10β1 (XSTEM-OA) in Adult Patients with Symptomatic Knee Osteoarthr
2023 | Musculoskeletal | Phase First-in-Human, I, IIa | Knee Osteoarthritis
A Multiple Arm, Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm, Phase 2 Study of Intra-Articular Administration of an Allogeneic Human Placental Tissue Particulate (PTP-001) for the Treatment of Knee Osteoarthritis.
2022 | Musculoskeletal | Phase II | Knee Osteoarthritis
A 5-year, Randomized, Double-blind, Placebo-controlled, Multi-center Study Assessing the Efficacy, Safety, and Tolerability of Intra-articular Regimens of LNA043 Versus Placebo in Patients With Symptomatic Knee Osteoarthritis (ONWARDS).
2021 | Musculoskeletal | Phase IIb | Knee Osteoarthritis
Upadacitinib treatment patterns, achievement of treatment targets and maintenance of response in moderate to severe Rheumatoid Arthritis patients in real-world practice (UPHOLD).
2020 | Musculoskeletal | Phase Post-Market | Rheumatoid Arthritis
Real World Effectiveness of Upadacitinib on Early and Sustained Pain Control in Radiographic Axial Spondyloarthritis (UPSTAND).
2021 | Musculoskeletal | Phase Post-Market | Spondyloarthritis
A Randomized, Active-Controlled, Parallel Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis.
2021 | Musculoskeletal | Phase IIIb, IV | Rheumatoid Arthritis
A Multicenter Open-Label Study Of Etanercept Withdrawal And Retreatment In Subjects With Non-Radiographic Axial Spondyloarthritis Who Achieved Adequate 24 Week Response.
2016 | Musculoskeletal | Phase IV | Spondyloarthritis
A Phase 3b/4 Randomized Double-Blind Placebo Controlled Study Of Methotrexate (Mtx) Withdrawal In Subjects With Rheumatoid Arthritis (Ra) Treated With Tofacitinib 11mg Modified Release (Mr) Formulation.
2017 | Musculoskeletal | Phase IIIb, IV | Rheumatoid Arthritis
A 12 Week Randomized, Double-Blind, Double Dummy, Parallel Group, Active And Placebo-Controlled, Multicenter Study To Assess The Efficacy And Safety Profile Of Pf-06650833 In Subjects With Active Rheumatoid Arthritis With An Inadequate Response To Methotr
2017 | Musculoskeletal | Phase II | Rheumatoid Arthritis
A Phase 3, Randomized, Double blind, Placebo controlled Study to Evaluate the Efficacy and Safety of Filgotinib in Subjects with Active Psoriatic Arthritis Who Have an Inadequate Response or are Intolerant to Biologic DMARD Therapy.
2020 | Musculoskeletal | Phase III | Psoriatic Arthritis
A Phase 3, Randomized, Double-blind, Placebo and Adalimumab-controlled Study to Evaluate the Efficacy and Safety of Filgotinib in Subjects with Active Psoriatic Arthritis Who Are Naïve to Biologic DMARD Therapy.
2020 | Musculoskeletal | Phase III | Psoriatic Arthritis
A randomized, double-blind, placebo-controlled study of the safety and efficacy of AA4500 for the treatment of adhesive capsulitis of the shoulder.
2014 | Musculoskeletal | Phase IIb | Other
An Open-label Historically Controlled Study to Assess the Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects with Multiple Dupuytren's Contractures with Palpable Cords.
2012 | Musculoskeletal | Phase IIIb | Other
Dose-Ranging Study of Multiple Subcutaneous Doses of LY2127399, an Anti-BAFF Human Antibody, in Participants with Active Rheumatoid Arthritis despite Ongoing Methotrexate Therapy.
2010 | Musculoskeletal | Phase II | Rheumatoid Arthritis
A Study to Compare the Preference for Two Contrasting Paracetamol Formulations In The Management of Osteoarthritis Pain.
2008 | Musculoskeletal | Phase IV | Knee Osteoarthritis
A Multi-Centre, Randomised, Double-Blind, Placebo Controlled, Parallel Group Exploratory Study to Investigate the Efficacy, Safety and Tolerability of AD 337 in the Treatment of Fibromyalgia in Female Subjects.
2007 | Musculoskeletal | Phase II | Fibromyalgia
A Randomised Double-Blind, Placebo-and-Active-Control, Parallel-arm, Phase III Trial with Controlled Adjustment of Dose to Evaluate the Efficacy and Safety of CG5503 Extended –Release (ER) in Subjects with Moderate to Severe Pain Due to Osteoarthritis of
2008 | Musculoskeletal | Phase III | Knee Osteoarthritis
A Randomized, Double Blind, Parallel-Group Study of Cardiovascular Safety in Osteoarthritis or Rheumatoid Arthritis Patients with or At High Risk for Cardiovascular Disease Comparing Celecoxib with Naproxen and Ibuprofen.
2011 | Musculoskeletal | Phase IV | Rheumatoid Arthritis
A Double Blind, Randomised, Parallel Group, Dose-Ranging Study Comparing FX006 to Commercially Available Triamcinolone Acetonide Injectable Suspension in Patients with Osteoarthritis of the Knee.
2012 | Musculoskeletal | Phase II | Knee Osteoarthritis
A Multi centre, Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Hydros and Hydros-TA Joint Therapies for Management of Pain Associated with Osteoarthritis in the Knee.
2015 | Musculoskeletal | Phase III | Knee Osteoarthritis
A Double-Blind, Randomized, Single-Dose Study to Assess the Safety and Efficacy of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee.
2016 | Musculoskeletal | Phase III | Knee Osteoarthritis
A Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of AXS-02 (Disodium Zoledronate Tetrahydrate) Administered Orally to Subjects with Knee Osteoarthritis Associated with Bone Marrow Lesions.
2016 | Musculoskeletal | Phase IIa | Knee Osteoarthritis
A randomised, double-blind using blinded evaluator, placebo and active controlled, pilot study to evaluate the safety and efficacy of intra articular administration of Articul One in patient with symptomatic primary knee osteoarthritis.
2017 | Musculoskeletal | Phase II | Knee Osteoarthritis
A Phase 2A, Randomized, Double-Blind, Placebo-Controlled, Multiple Center, Multiple-Dose Study to Assess the Efficacy and Safety of ZYN002 Administered as a Transdermal Gel to Patients with Knee Pain due to Osteoarthritis.
2017 | Musculoskeletal | Phase IIa | Knee Osteoarthritis
A Phase IIa, Randomized, Double-blinded, Placebo-controlled, Dose-finding Study for Single-Dose Administration of TLC599 in Patients with Osteoarthritis (OA) of Knee.
2017 | Musculoskeletal | Phase IIa | Knee Osteoarthritis
A Phase 3, Randomized, Double-blind, Placebo- and Active controlled Study to Evaluate the Efficacy and Safety of TLC599 in Patients with Osteoarthritis of the Knee.
2020 | Musculoskeletal | Phase III | Knee Osteoarthritis
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects with Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH) and Fibrosis/Metabolic Dysfunction-Associated Steatohepatitis (MASH) And Fi
2024 | Pharmaceutical - Other | Phase III | Nonalcoholic Fatty Liver Disease
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects with Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH)
2024 | Pharmaceutical - Other | Phase III | Nonalcoholic Fatty Liver Disease
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects with Non-Invasively Diagnosed Nonalcoholic Steatohepatitis (NASH)/Nonalcoholic Fatty Liver Disease (NAFLD)
2024 | Pharmaceutical - Other | Phase III
XanaCIDD: A Double-Blind, Randomized, Placebo Controlled, Parallel-Group Trial to Assess the Safety, Tolerability, and Efficacy of Xanamem® in Adults With Major Depressive Disorder and Impaired Cognition.
2023 | Pharmaceutical - Other | Phase II
A multi-centre, randomised, double-blind, placebo-controlled, parallel group, multiple dose, study of the efficacy of 8.75mg Flurbiprofen micro granules in the relief of sore throat due to upper respiratory tract infection.
2009 | Pharmaceutical - Other | Phase III | Other
A Multi-Centre, Randomised, Double-Blinded, Placebo Controlled, Parallel Group, Multiple Dose Study of the Efficacy of 8.75mg Flurbiprofen Spray in the Relief of Sore Throat due to URTI.
2012 | Pharmaceutical - Other | Phase III | Other
A Randomized, Double-Blind, Parallel-Group, Placebo- and Active- Controlled, Multi-center Study to Evaluate the Efficacy, Safety and Tolerability of Combinations of Solifenacin Succinate and Mirabegron Compared to Solifenacin Succinate and Mirabegron Mono
2013 | Pharmaceutical - Other | Phase III | Overactive Bladder
A Randomized, Double-Blind, Parallel-Group, Active-Controlled, Multi-center Study to Evaluate the Long-Term Safety and Efficacy of Combination of Solifenacin Succinate with Mirabegron Compared to Solifenacin Succinate and Mirabegron Monotherapy in Subject
2013 | Pharmaceutical - Other | Phase III | Overactive Bladder
A Phase I/IIa study to investigate the safety and efficacy of APC201 for the treatment of pain associated with osteoarthritis of the knee
2023 | Pharmaceutical - Pain | Phase II | Knee Osteoarthritis
A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Crossover Study to Assess the Efficacy, Safety, and Tolerability of SR419 in Patients with Postherpetic Neuralgia (PHN).
2022 | Pharmaceutical - Pain | Phase II | Neuropathic Pain, Postherpetic Neuralgia
A Randomized, Double-Blind, Placebo- Controlled, Multicentre Phase III Study to Evaluate the Efficacy and Safety of Alvimopan 0.5mg Once Daily and 0.5mg Twice Daily for12 weeks for the Treatment of Opioid-Induced Bowel Dysfunction in Adults taking Opioid
2006 | Pharmaceutical - Pain | Phase III | Pain - General
A Randomized, Double-Blind, Placebo- Controlled, Multicentre Phase III Study to Evaluate the Long-Term Safety of Alvimopan 0.5mg Twice Daily for 12 Months for the Treatment of Opioid-Induced Bowel Dysfunction in Adults taking Opioid Therapy for Persistent
2007 | Pharmaceutical - Pain | Phase III | Pain - General
A Randomised Double-Blind, Placebo-and-Active-Control, Parallel-arm, Phase III Trial with Controlled Adjustment of Dose to Evaluate the Efficacy and Safety of CG5503 Extended –Release (ER) in Subjects with Moderate to Severe Chronic Low Back Pain.
2008 | Pharmaceutical - Pain | Phase III | Back and/or Leg Pain
A Double-Blind Placebo-Controlled study of the efficacy and safety of the p38 Map kinase inhibitor SB681323 in patients with neuropathic pain following nerve trauma.
2009 | Pharmaceutical - Pain | Phase II | Neuropathic Pain
A randomised, double-blind, placebo-controlled study of the efficacy and safety of a diclofenac sodium patch for the topical treatment of acute pain due to mild to moderate soft tissue injuries.
2009 | Pharmaceutical - Pain | Phase III | Pain - General
A Multicentre, Randomised, Double-Blind, Parallel Group Comparison of The Efficacy and Safety of Transdermal Buprenorphine (Norspan® TDS) And Placebo in Participants with Post Herpetic Neuralgia.
2010 | Pharmaceutical - Pain | Phase III, IV | Postherpetic Neuralgia
Open-label study to evaluate the Long-Term Safety of Subcutaneous MOA-728 for Treatment of Opioid-Induced Constipation in Subjects with Non-malignant Pain.
2010 | Pharmaceutical - Pain | Phase III | Pain - General
A confirmatory, placebo-controlled, randomised, double-blind, single dummy, parallel group, ratio-finding study in constipated pain patients to establish an optimal Hydromorphone – naloxone ratio with an improved bowel function and a comparable analgesic
2011 | Pharmaceutical - Pain | Phase II, III | Pain - General
Efficacy and safety of Transdermal Buprenorphine (Norspan BTDS) and placebo in patients with Diabetic Peripheral Neuropathic Pain (DPNP).
2011 | Pharmaceutical - Pain | Phase IIIb | Painful Diabetic Neuropathy
Use of Duloxetine or Pregabalin in Monotherapy versus Combination Therapy of Both Drugs in Patients with Painful Diabetic Neuropathy "The COMBO – DN" (Combination vs Monotherapy of Pregabalin and duloxetine in Diabetic Neuropathy).
2012 | Pharmaceutical - Pain | Phase IIIb | Painful Diabetic Neuropathy
A randomised, double-blind, double-dummy, parallel-group multicentre study to demonstrate improvement in symptoms of constipation and noninferiority in analgesic efficacy in subjects with non-malignant or malignant pain that requires around-the-clock opio
2012 | Pharmaceutical - Pain | Phase III | Pain - General
A Phase I/IIa, Multicenter, Open-label, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration.
2013 | Pharmaceutical - Pain | Phase I, IIa | Back and/or Leg Pain
A Randomized, Double-Blind, Crossover, Phase IIa Study Comparing a Single-Application TPM®/Oxycodone Patch versus Vehicle Patch in the Topical Treatment of Patients with Postherpetic Neuralgia.
2015 | Pharmaceutical - Pain | Phase IIa | Postherpetic Neuralgia
CREATE-1: A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Disodium Zoledronate Tetrahydrate) Administered Orally to Subjects with Complex Regional Pain Syndrome Type I (CRPS-I).
2016 | Pharmaceutical - Pain | Phase III | CRPS
A Phase II, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of topical Lidocaine Spray in Patients with Postherpetic Neuralgia.
2018 | Pharmaceutical - Pain | Phase II | Postherpetic Neuralgia
A double-blind, placebo-controlled, randomized trial to determine the safety and efficacy of EMA401 100 mg b.i.d. in reducing 24-hour average pain intensity score in patients with painful diabetic neuropathy (EMPADINE).
2018 | Pharmaceutical - Pain | Phase II | Painful Diabetic Neuropathy
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of Respiratory Syncytial Virus Prefusion F Subunit Vaccine when Coadministered with Seasonal Inactivated Influenza Vaccine in Adults ≥65
2022 | Vaccine | Phase III | Healthy
A Phase 2, Randomized, Observer-Blinded Study to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 rS Nanoparticle and Quadrivalent Hemagglutinin Nanoparticle Influenza Combination Vaccine With Matrix-M™ Adjuvant in Healthy Participants ≥ 50 to ≤ 80
2023 | Vaccine | Phase II | Healthy
A Multicenter, Randomized, Double Blind, Placebo-Controlled, Phase 3 Study to Determine if RTB101 Prevents Clinically Symptomatic Respiratory Illness in the Elderly.
2019 | Vaccine | Phase III | Healthy
A Randomized, Double-blind, Placebo-controlled Phase 2b Study to Assess the Efficacy, Immunogenicity and Safety of an Ad26.RSV.preF-based Regimen in the Prevention of RT-PCR-confirmed RSV-mediated Lower Respiratory Tract Disease in Adults Aged 65 Years an
2019 | Vaccine | Phase IIb | Healthy
A Randomised, Double-Blinded Study to Assess Safety, Immunogenicity, and Lot Consistency of Solvay's Cell Derived Influenza Vaccine.
2010 | Vaccine | Phase III | Healthy
A Randomized, Observer-Blind with Single-Blind Booster, Multi Centre, Study to Evaluate Safety, Tolerability and Immunogenicity of an Adjuvanted Cell Culture-Derived H5N1 Subunit Influenza Virus Vaccine at Two Different Formulations in Healthy Adult and E
2013 | Vaccine | Phase II | Healthy
A Phase 2b Study to Determine the Efficacy of Candidate Influenza Vaccine MVA-NP+M1 in Adults aged 18 years and over.
2019 | Vaccine | Phase IIb | Healthy